A Universal Code for mRNA Stability?

Ying Hsin Chen; Jeff Coller

doi:10.1016/j.tig.2016.08.007

A Universal Code for mRNA Stability?

Research output: Contribution to journal › Short survey › peer-review

Abstract

Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.

Original language	English (US)
Pages (from-to)	687-688
Number of pages	2
Journal	Trends in Genetics
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.tig.2016.08.007
State	Published - Nov 1 2016
Externally published	Yes

Keywords

codon optimality
deadenylation
mRNA decay
maternal-to-zygotic transition
translation

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2016.08.007

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@article{c7b8b5ed82914a58bb632300f431a148,

title = "A Universal Code for mRNA Stability?",

abstract = "Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.",

keywords = "codon optimality, deadenylation, mRNA decay, maternal-to-zygotic transition, translation",

author = "Chen, {Ying Hsin} and Jeff Coller",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.tig.2016.08.007",

language = "English (US)",

volume = "32",

pages = "687--688",

journal = "Trends in Genetics",

issn = "0168-9525",