A Universal Code for mRNA Stability?

Ying Hsin Chen, Jeff Coller

Research output: Contribution to journalShort surveypeer-review

Abstract

Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.

Original languageEnglish (US)
Pages (from-to)687-688
Number of pages2
JournalTrends in Genetics
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • codon optimality
  • deadenylation
  • mRNA decay
  • maternal-to-zygotic transition
  • translation

ASJC Scopus subject areas

  • Genetics

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