Abstract
Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.
Original language | English (US) |
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Pages (from-to) | 687-688 |
Number of pages | 2 |
Journal | Trends in Genetics |
Volume | 32 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2016 |
Externally published | Yes |
Keywords
- codon optimality
- deadenylation
- mRNA decay
- maternal-to-zygotic transition
- translation
ASJC Scopus subject areas
- Genetics