Abstract
Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.
Original language | English (US) |
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Pages (from-to) | 7609-7613 |
Number of pages | 5 |
Journal | Journal of bacteriology |
Volume | 191 |
Issue number | 24 |
DOIs | |
State | Published - Dec 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology