A typhus group-specific protease defies reductive evolution in rickettsiae

Nicole C. Ammerman, Joseph J. Gillespie, Andrew F. Neuwald, Bruno W. Sobral, Abdu F. Azad

Research output: Contribution to journalArticlepeer-review


Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.

Original languageEnglish (US)
Pages (from-to)7609-7613
Number of pages5
JournalJournal of bacteriology
Issue number24
StatePublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


Dive into the research topics of 'A typhus group-specific protease defies reductive evolution in rickettsiae'. Together they form a unique fingerprint.

Cite this