A two-year longitudinal study of poststroke mood disorders: In-hospital prognostic factors associated with six-month outcome

Robert G. Robinson, Lyn Book Starr, John R. Lipsey, Krishna Rao, Thomas R. Price

Research output: Contribution to journalArticlepeer-review

Abstract

In a prospective study of mood disorders in stroke patients, variables obtained during the acute hospitalization were examined for their relationship to outcome at either 3-or 6-month follow-up. Distance of the lesion on computerized axial tomography scan from the frontal pole in patients with left anterior infarcts was significantly associated with severity of depression at 3 and 6 months poststroke. In addition, intellectual and functional physical impairment in-hospital were significantly correlated with severity of depression and social functioning scores at 3 and 6 months poststroke. Thus, patients who develop depression during the first 6 months poststroke may be responding to the severity of their impairment whereas the patients who develop depressions during the acute poststroke period may have a neuroanatomical and neurophysiological basis for their depression. Although other explanations might be proposed, the dynamic nature of the relationship between depression and associated variables during the first 6 months poststroke indicates that etiology of poststroke depression may be different depending upon the time of onset of the depression after brain injury.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalJournal of Nervous and Mental Disease
Volume173
Issue number4
DOIs
StatePublished - Apr 1985

ASJC Scopus subject areas

  • Psychiatry and Mental health

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