A twisted hand: bHLH protein phosphorylation and dimerization regulate limb development

Medicine & Life Sciences

• Protein Multimerization 100%
• Acrocephalosyndactylia 73%
• Hand 49%
• Extremities 48%
• Phosphorylation 45%
• Basic Helix-Loop-Helix Transcription Factors 22%
• Haploinsufficiency 20%
• Craniosynostoses 20%
• Dimerization 18%
• Loss of Function Mutation 18%
• Ectopic Gene Expression 17%
• Proteins 12%
• Amino Acids 11%
• Phenotype 9%

Agriculture & Biology

• dimerization 79%
• protein phosphorylation 72%
• limbs (animal) 63%
• hands 55%
• haploinsufficiency 28%
• basic helix-loop-helix transcription factors 23%
• loss-of-function mutation 20%
• pathogenesis 14%
• phosphorylation 14%
• proteins 11%
• phenotype 10%
• mice 9%
• amino acids 9%
• dosage 8%

Chemical Compounds

• Dimerization 59%
• Amino-Acid Residue 29%
• Mutation 27%
• Protein 26%