A Tunable Reentrant Resonator with Transverse Orientation of Electric Field for in Vivo EPR Spectroscopy

Michael Chzhan, Periannan Kuppusamy, Alexandre Samouilov, Guanglong He, Jay L. Zweier

Research output: Contribution to journalArticle

Abstract

There has been a need for development of microwave resonator designs optimized to provide high sensitivity and high stability for EPR spectroscopy and imaging measurements of in vivo systems. The design and construction of a novel reentrant resonator with transversely oriented electric field (TERR) and rectangular sample opening cross section for EPR spectroscopy and imaging of in vivo biological samples, such as the whole body of mice and rats, is described. This design with its transversely oriented capacitive element enables wide and simple setting of the center frequency by trimming the dimensions of the capacitive plate over the range 100-900 MHz with unloaded Q values of approximately 1100 at 750 MHz, while the mechanical adjustment mechanism allows smooth continuous frequency tuning in the range ± 50 MHz. This orientation of the capacitive element limits the electric field based loss of resonator Q observed with large lossy samples, and it facilitates the use of capacitive coupling. Both microwave performance data and EPR measurements of aqueous samples demonstrate high sensitivity and stability of the design, which make it well suited for in vivo applications.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalJournal of Magnetic Resonance
Volume137
Issue number2
StatePublished - Apr 1999

Keywords

  • EPR imaging
  • Free radical measurement
  • In vivo EPR spectroscopy
  • Reentrant resonator
  • Transversely oriented electric field

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'A Tunable Reentrant Resonator with Transverse Orientation of Electric Field for in Vivo EPR Spectroscopy'. Together they form a unique fingerprint.

  • Cite this

    Chzhan, M., Kuppusamy, P., Samouilov, A., He, G., & Zweier, J. L. (1999). A Tunable Reentrant Resonator with Transverse Orientation of Electric Field for in Vivo EPR Spectroscopy. Journal of Magnetic Resonance, 137(2), 373-378.