A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: Further support for a susceptibility locus for schizophrenia at 22q12

Schizophrenia Collaborative Linkage Group for Chromosome 22

Research output: Contribution to journalArticle

Abstract

Previously, a combined analysis by the Chromosome 22 Collaborative Linkage Group (1996; Am. J. Med Genet. 67, 40-45) used an affected sib-pair analysis of a single marker (D22S278) in 574 families multiply affected by schizophrenia and found some evidence for linkage (λ2 = 9.35, 1 df, p = 0.001), suggesting the presence of a disease locus nearby on chromosome 22q12. In order to further investigate the importance of this result, we have performed the transmission disequilibrium test (TDT) and additional parametric and non-parametric linkage analysis of the same data. The most positive result obtained was an admixture lod score of 0.9 under the assumption of locus heterogeneity and dominant transmission. The result of the TDT analysis was significant at p = 0.015 (allele-wise; λ2 = 22, 10 df) and p = 0.00016 (genotype-wise; λ2 = 66.2, 30 df, empirical p value = 0.0009). Overall, these results further strengthen the notion that there is a susceptibility locus for schizophrenia close to D22S278.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalSchizophrenia Research
Volume32
Issue number2
DOIs
StatePublished - Jul 27 1998

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Keywords

  • Chromosome 22
  • Combined analysis
  • Complex disease genetics
  • Psychosis
  • TDT

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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