A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region

Debra L. Weinstat-Saslow, Gregory G. Germino, Stefan Somlo, Stephen T. Reeders

Research output: Contribution to journalArticlepeer-review

Abstract

A novel human gene (sazD) that maps to the autosomaldominant polycystic kidney disease region shares sequence similarity with members of the β-transducin superfamily. The cDNA sazD-c predicts an ∼58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.

Original languageEnglish (US)
Pages (from-to)709-711
Number of pages3
JournalGenomics
Volume18
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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