A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region

Debra L. Weinstat-Saslow; Gregory G. Germino; Stefan Somlo; Stephen T. Reeders

doi:10.1016/S0888-7543(05)80380-5

A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region

Debra L. Weinstat-Saslow, Gregory G. Germino, Stefan Somlo, Stephen T. Reeders

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A novel human gene (sazD) that maps to the autosomaldominant polycystic kidney disease region shares sequence similarity with members of the β-transducin superfamily. The cDNA sazD-c predicts an ∼58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.

Original language	English (US)
Pages (from-to)	709-711
Number of pages	3
Journal	Genomics
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/S0888-7543(05)80380-5
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Genetics

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abstract = "A novel human gene (sazD) that maps to the autosomaldominant polycystic kidney disease region shares sequence similarity with members of the β-transducin superfamily. The cDNA sazD-c predicts an ∼58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.",

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AU - Germino, Gregory G.

AU - Somlo, Stefan

AU - Reeders, Stephen T.

PY - 1993

Y1 - 1993

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AB - A novel human gene (sazD) that maps to the autosomaldominant polycystic kidney disease region shares sequence similarity with members of the β-transducin superfamily. The cDNA sazD-c predicts an ∼58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.

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A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region

Abstract

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