TY - JOUR
T1 - A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders
T2 - An international Delphi consensus study
AU - Fontenelle, Leonardo F.
AU - Oldenhof, Erin
AU - Eduarda Moreira-de-Oliveira, Maria
AU - Abramowitz, Jonathan S.
AU - Antony, Martin M.
AU - Cath, Danielle
AU - Carter, Adrian
AU - Dougherty, Darin
AU - Ferrão, Ygor A.
AU - Figee, Martijn
AU - Harrison, Ben J.
AU - Hoexter, Marcelo
AU - Soo Kwon, Jun
AU - Küelz, Anne
AU - Lazaro, Luísa
AU - Lochner, Christine
AU - Marazziti, Donatella
AU - Mataix-Cols, David
AU - McKay, Dean
AU - Miguel, Euripedes C.
AU - Morein-Zamir, Sharon
AU - Moritz, Steffen
AU - Nestadt, Gerald
AU - O’Connor, Kieron
AU - Pallanti, Stefano
AU - Purdon, Christine
AU - Rauch, Scott
AU - Richter, Peggy
AU - Rotge, Jean Yves
AU - Shavitt, Roseli G.
AU - Soriano-Mas, Carles
AU - Starcevic, Vladan
AU - Stein, Dan J.
AU - Steketee, Gail
AU - Storch, Eric A.
AU - Taylor, Steven
AU - van den Heuvel, Odile A.
AU - Veale, David
AU - Woods, Douglas W.
AU - Verdejo-Garcia, Antonio
AU - Yücel, Murat
N1 - Publisher Copyright:
© The Royal Australian and New Zealand College of Psychiatrists 2020.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Background: The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders. Methods: Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given. Results: Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by ⩾75% of experts as ‘primary constructs’ and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity). Conclusion: This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.
AB - Background: The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders. Methods: Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given. Results: Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by ⩾75% of experts as ‘primary constructs’ and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity). Conclusion: This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.
KW - Obsessive-compulsive and related disorders
KW - Research Domain Criteria
KW - cognitive control
KW - compulsivity
KW - habit
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U2 - 10.1177/0004867420912327
DO - 10.1177/0004867420912327
M3 - Article
C2 - 32364439
AN - SCOPUS:85085020532
SN - 0004-8674
VL - 54
SP - 719
EP - 731
JO - Australian and New Zealand Journal of Psychiatry
JF - Australian and New Zealand Journal of Psychiatry
IS - 7
ER -