TY - JOUR
T1 - A toxicology for the 21st century - Mapping the road ahead
AU - Hartung, Thomas
N1 - Funding Information:
As a first step, with the financial support of the Doerenkamp-Zbinden foundation (http://www.doerenkamp.ch/en/) which have been created in recent years five professorships for alternative
PY - 2009
Y1 - 2009
N2 - The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together.
AB - The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together.
KW - Toxicity testing
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U2 - 10.1093/toxsci/kfp059
DO - 10.1093/toxsci/kfp059
M3 - Article
C2 - 19357069
AN - SCOPUS:65549145511
SN - 1096-6080
VL - 109
SP - 18
EP - 23
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 1
ER -