A Tourette-like syndrome following cardiopulmonary bypass and hypothermia: MRI volumetric measurements

Harvey Singer, Pablito S. Dela Cruz, Michael T. Abrams, S. Charles Bean, Allan L. Reiss

Research output: Contribution to journalArticle

Abstract

We present the case of an adolescent boy who developed a variety of simple and complex motor and vocal tics (Tourette-like syndrome), along with inattentiveness and obsessive-compulsive behaviors after cardiac surgery with cardiopulmonary bypass and profound hypothermia. A single photon emission computed tomography study 2 months after surgery showed reduced uptake in the left hemisphere and 2 years later a perfusion defect in the basal ganglia. Serial magnetic resonance imaging (MRI) studies were normal. Volumetric MRI studies were obtained 4 years after surgery and compared with published values for normal individuals and children with Tourette syndrome (TS), including subsets matched for age, sex, and handedness. Measurement of basal ganglia structures showed a right-dominant asymmetry of the caudate and putamen, in part similar to findings previously reported in patients with TS. Other volumetric abnormalities included a > 2-SD reduction of cortical gray matter, a small decrease of total cerebral volume, and increase in cerebral white matter. Although a variety of neurological problems may occur after cardiopulmonary bypass, to our knowledge this case represents the first report of a chronic tic disorder following cardiac surgery with cardiopulmonary bypass and hypothermia.

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalMovement disorders : official journal of the Movement Disorder Society
Volume12
Issue number4
DOIs
StatePublished - 1997

Fingerprint

Tourette Syndrome
Hypothermia
Cardiopulmonary Bypass
Tics
Magnetic Resonance Imaging
Basal Ganglia
Thoracic Surgery
Tic Disorders
Compulsive Behavior
Obsessive Behavior
Functional Laterality
Putamen
Single-Photon Emission-Computed Tomography
Reference Values
Perfusion

Keywords

  • Attention-deficit hyperactivity disorder
  • Cardiopulmonary bypass
  • Hypothermia
  • Obsessive-compulsive disorder
  • Tics
  • Tourette syndrome
  • Volumetric measurements

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

A Tourette-like syndrome following cardiopulmonary bypass and hypothermia : MRI volumetric measurements. / Singer, Harvey; Dela Cruz, Pablito S.; Abrams, Michael T.; Bean, S. Charles; Reiss, Allan L.

In: Movement disorders : official journal of the Movement Disorder Society, Vol. 12, No. 4, 1997, p. 588-592.

Research output: Contribution to journalArticle

Singer, Harvey ; Dela Cruz, Pablito S. ; Abrams, Michael T. ; Bean, S. Charles ; Reiss, Allan L. / A Tourette-like syndrome following cardiopulmonary bypass and hypothermia : MRI volumetric measurements. In: Movement disorders : official journal of the Movement Disorder Society. 1997 ; Vol. 12, No. 4. pp. 588-592.
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