TY - JOUR
T1 - A tool to predict suicidal ideation and behavior in bipolar disorder
T2 - The Concise Health Risk Tracking Self-Report
AU - Reilly-Harrington, Noreen A.
AU - Shelton, Richard C.
AU - Kamali, Masoud
AU - Rabideau, Dustin J.
AU - Shesler, Leah W.
AU - Trivedi, Madhukar H.
AU - McElroy, Susan L.
AU - Sylvia, Louisa G.
AU - Bowden, Charles L.
AU - Ketter, Terence A.
AU - Calabrese, Joseph R.
AU - Thase, Michael E.
AU - Bobo, William V.
AU - Deckersbach, Thilo
AU - Tohen, Mauricio
AU - McInnis, Melvin G.
AU - Kocsis, James H.
AU - Gold, Alexandra K.
AU - Singh, Vivek
AU - Finkelstein, Daniel M.
AU - Kinrys, Gustavo
AU - Nierenberg, Andrew A.
N1 - Publisher Copyright:
© 2016 Published by Elsevier B.V.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76% for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.
AB - Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76% for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.
KW - Bipolar disorder
KW - Psychometrics
KW - Risk
KW - Self-report
KW - Suicide
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U2 - 10.1016/j.jad.2015.12.036
DO - 10.1016/j.jad.2015.12.036
M3 - Article
C2 - 26748736
AN - SCOPUS:84952787188
SN - 0165-0327
VL - 192
SP - 212
EP - 218
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -