A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider, Elizabeth H. Blackburn

Research output: Contribution to journalArticlepeer-review

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalNature
Volume337
Issue number6205
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • General

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