A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones

Ravindra De Silva, Soumava Santra, Peter R. Andreana

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugl condensation reaction, microwave irradiation, and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or C2, N4 substitution (B).

Original languageEnglish (US)
Pages (from-to)4541-4544
Number of pages4
JournalOrganic Letters
Volume10
Issue number20
DOIs
StatePublished - 2008
Externally publishedYes

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Reducing Agents
Microwaves
Substitution reactions
substitutes
microwaves
Condensation reactions
Microwave irradiation
synthesis
condensation
routes
irradiation

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

A tandem one-pot, microwave-assisted synthesis of regiochemically differentiated 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones. / De Silva, Ravindra; Santra, Soumava; Andreana, Peter R.

In: Organic Letters, Vol. 10, No. 20, 2008, p. 4541-4544.

Research output: Contribution to journalArticle

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