A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimetic receptor gene recognizing a human ovarian cancer antigen

Gang Wang, Rajesh K. Chopra, Richard E. Royal, James C. Yang, Steven A. Rosenberg, Patrick Hwu

Research output: Contribution to journalArticle

Abstract

In order to treat common cancers with immunotherapy, chimeric receptors have been developed that combine the tumor specificity of antibodies with T- cell effector functions. Previously, we demonstrated that T cells transduced with a chimeric receptor gene against human ovarian cancer were able to recognize ovarian cancer cells in vitro and in vivo. We now report that recipients of bone marrow cells transduced with these genes exhibited significant antitumor activity in vivo. Moreover, in vivo depletion of T cells in reconstituted mice did not affect antitumor activity, suggesting that other immune cells expressing the chimeric receptor gene may play an important role in tumor rejection.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalNature Medicine
Volume4
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

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T-cells
Bone Marrow Cells
Ovarian Neoplasms
Bone
Genes
Cells
T-Lymphocytes
Antigens
Antibodies
Tumors
Neoplasm Antibodies
Immunotherapy
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimetic receptor gene recognizing a human ovarian cancer antigen. / Wang, Gang; Chopra, Rajesh K.; Royal, Richard E.; Yang, James C.; Rosenberg, Steven A.; Hwu, Patrick.

In: Nature Medicine, Vol. 4, No. 2, 1998, p. 168-172.

Research output: Contribution to journalArticle

Wang, Gang ; Chopra, Rajesh K. ; Royal, Richard E. ; Yang, James C. ; Rosenberg, Steven A. ; Hwu, Patrick. / A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimetic receptor gene recognizing a human ovarian cancer antigen. In: Nature Medicine. 1998 ; Vol. 4, No. 2. pp. 168-172.
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