TY - JOUR
T1 - A systems biology view of blood vessel growth and remodelling
AU - Logsdon, Elizabeth A.
AU - Finley, Stacey D.
AU - Popel, Aleksander S.
AU - MacGabhann, Feilim
N1 - Publisher Copyright:
© 2013 The Authors.
PY - 2014
Y1 - 2014
N2 - Blood travels throughout the body in an extensive network of vessels - arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels - arterioles, venules and capillaries - can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis - the sprouting of new blood vessels - and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.
AB - Blood travels throughout the body in an extensive network of vessels - arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels - arterioles, venules and capillaries - can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis - the sprouting of new blood vessels - and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.
KW - Angiogenesis
KW - Computational model
KW - Mathematical model
KW - Multi-scale modelling
KW - Systems biology
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U2 - 10.1111/jcmm.12164
DO - 10.1111/jcmm.12164
M3 - Article
C2 - 24237862
AN - SCOPUS:84912572768
SN - 1582-1838
VL - 18
SP - 1491
EP - 1508
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
IS - 8
ER -