A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

James Handa, Cathy Bowes Rickman, Andrew D. Dick, Michael B. Gorin, Joan W. Miller, Cynthia A. Toth, Marius Ueffing, Marco Zarbin, Lindsay A. Farrer

Research output: Contribution to journalArticle

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

Original languageEnglish (US)
Article number3347
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

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Systems Biology
degeneration
Macular Degeneration
biology
therapy
Biomarkers
blindness
biomarkers
Mathematical models
progressions
monitors
mathematical models
Blindness
Therapeutics
Disease Progression
Theoretical Models
causes
Pharmacology
Direction compound

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. / Handa, James; Bowes Rickman, Cathy; Dick, Andrew D.; Gorin, Michael B.; Miller, Joan W.; Toth, Cynthia A.; Ueffing, Marius; Zarbin, Marco; Farrer, Lindsay A.

In: Nature communications, Vol. 10, No. 1, 3347, 01.12.2019.

Research output: Contribution to journalArticle

Handa, J, Bowes Rickman, C, Dick, AD, Gorin, MB, Miller, JW, Toth, CA, Ueffing, M, Zarbin, M & Farrer, LA 2019, 'A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration', Nature communications, vol. 10, no. 1, 3347. https://doi.org/10.1038/s41467-019-11262-1
Handa, James ; Bowes Rickman, Cathy ; Dick, Andrew D. ; Gorin, Michael B. ; Miller, Joan W. ; Toth, Cynthia A. ; Ueffing, Marius ; Zarbin, Marco ; Farrer, Lindsay A. / A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. In: Nature communications. 2019 ; Vol. 10, No. 1.
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