@article{89cb1d57a57648368676c5b196798712,
title = "A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration",
abstract = "Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.",
author = "Handa, {James T.} and {Bowes Rickman}, Cathy and Dick, {Andrew D.} and Gorin, {Michael B.} and Miller, {Joan W.} and Toth, {Cynthia A.} and Marius Ueffing and Marco Zarbin and Farrer, {Lindsay A.}",
note = "Funding Information: Competing interests: J.T.H.: Grant funding from Bayer Pharmaceuticals, Inc. J.W.M.: Consultant/Advisor for Genentech/Roche, Bausch+Lomb, Kalvista Pharmaceuticals, ONL Therapeutics; Grant Support from Lowy Medical Research Institute; Equity in ONL Therapeutics; Patents/Royalties from ONL Therapeutics/Mass. Eye and Ear, Valeant Pharmaceuticals/Mass. Eye and Ear. C.A.T.: Alcon royalties for surgical technologies. M. Z.: Cell Cure, Chengdu Kanghong Biotech, Coherus Biosciences, Daiichi Sankyo, Frequency Therapeutics, Healios KK, Iridex, Isarna Therapeutics, Genentech/Roche, Makindus, Novartis Pharma AG, Ophthotech, Percept Corp., Rutgers University (patent). The remaining authors declare no competing interests. Funding Information: We thank Paul Sieving, MD, Ph.D., Director of the NEI and the National Eye Institute for organizing the AMD Pathobiology group. We also thank Anna E. Mazzucco, Ph.D. for her contributions to the group. J.T.H.: NIH EY027691; NIH R42 EY029625-01; BrightFocus Foundation; Macular Degeneration Foundation; Wilmer-Bayer Alliance Grant, Bayer Pharmaceuticals, Inc.; Unrestricted Grant from Research to Prevent Blindness (Wilmer Eye Institute), Robert Bond Welch Professorship. C.B.R.: NIH R01 EY026161; P30 EY005722 to Duke University, a Research to Prevent Blindness (RPB)/ International Retinal Research Foundation (IRRF) Catalyst Award for Innovative Research Approaches for AMD, an unrestricted grant from RPB (to the Duke Eye Center), and a Fighting Blindness Individual Investigator Award. A.D.D.: NIHR Biomedical Research Centre Moorfields Eye Hospital and UCL-Institute of Ophthalmology, National Eye Research Centre UK, Macular Society UK, Medical Research Council UK, Rosetrees Trust UK. M.B.G.: Harold and Pauline Price Foundation, Research to Prevent Blindness, NY, NY, NIH/NEI R01 EY09859 Gorin (PI). J.W.M.: NEI Core Facility Grant EY014104, Yeatts Retina Fund, Research to Prevent Blindness, Retina Research Fund, Champalimaud Vision Award. C.A.T.: an unrestricted grant from RPB (to the Duke Eye Center). M.U.: EYE-RISK is funded by the Horizon 2020 program of the European Union. Funding is provided to Marius Ueffing in the period of 2015–2019 under Grant Agreement number 634479. M.Z.: Joseph J. and Marguerite DiSepio Retina Research Fund; Eng Family Foundation; New Jersey Lions Eye Research Foundation; Paid Consultant for: California Institute of Regenerative Medicine, Cell Cure, Chengdu Kanghong Biotechnology Co., Coherus Biosciences, Inc., Daiichi Sankyo, Frequency Therapeutics, Foundation Fighting Blindness, Genentech/Roche, Healios KK, Inc., Iridex, Isarna Therapeutics, Makindus, Novartis Pharma AG, Ophthotech Corp., Percept Corp. L.A.F.: NIH U01-AG032984, NIH UF1-AG046198, NIH R01-AG048927, NIH RF1-AG057519. Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-11262-1",
language = "English (US)",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}