A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

Nikolaos A. Papanikolaou, Andrej Tillinger, Xiaoping Liu, Athanasios G. Papavassiliou, Esther L. Sabban

Research output: Contribution to journalArticle

Abstract

RESULTS: Using microarrays and network analysis we show here for the first time that the transcription factor signal transducer and activator of transcription 3 (Stat3) gene is activated in acute stress whereas the prolactin releasing hormone (Prlh11) and chromogranin B (Chgb) genes are induced in repeated immobilization stress and that along with Egr1 may be critical mediators of the stress response.

CONCLUSIONS: Our results suggest possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation.

BACKGROUND: Adaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and repeated stress, however the complexity of the response suggests that other transcription factor pathways might be playing equally important roles during acute and repeated stress. Therefore, we sought to discover such factors by applying a systems approach.

Original languageEnglish (US)
Pages (from-to)100
Number of pages1
JournalBMC Systems Biology
Volume8
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Early Growth Response Protein 1
Transcription factors
Chromogranin B
Transcription Factor
Systems Analysis
Immobilization
STAT3 Transcription Factor
Transcription Factors
Molecules
Prolactin-Releasing Hormone
Adrenal Medulla
Acute
Transcription
Microarray Analysis
Epinephrine
Genes
Transducers
Up-Regulation
Myocardial Infarction
Transducer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress. / Papanikolaou, Nikolaos A.; Tillinger, Andrej; Liu, Xiaoping; Papavassiliou, Athanasios G.; Sabban, Esther L.

In: BMC Systems Biology, Vol. 8, 2014, p. 100.

Research output: Contribution to journalArticle

Papanikolaou, Nikolaos A. ; Tillinger, Andrej ; Liu, Xiaoping ; Papavassiliou, Athanasios G. ; Sabban, Esther L. / A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress. In: BMC Systems Biology. 2014 ; Vol. 8. pp. 100.
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AU - Sabban, Esther L.

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