A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris

James Leyden, Wilma Bergfeld, Lynn Drake, Frank Dunlap, Mitchel P. Goldman, Alice B. Gottlieb, Michael P. Heffernan, Janet G. Hickman, Maria Hordinsky, Michael Jarrett, Sewon Kang, Ann Lucky, Gary Peck, Tania Phillips, Marvin Rapaport, Janet Roberts, Ronald Savin, Marty E. Sawaya, Alan Shalita, Joel ShavinJames C. Shaw, Linda Stein, Daniel Stewart, John Strauss, James Swinehart, Leonard Swinyer, Diane Thiboutot, Ken Washenik, Gerald Weinstein, David Whiting, Frances Pappas, Matilde Sanchez, Lisa Terranella, Joanne Waldstreicher

Research output: Contribution to journalArticle

Abstract

Excessive sebum production is a central aspect of the pathophysiology of acne vulgaris. Sebaceous gland function is under androgen control and it is hypothesized that dihydrotestosterone is formed by the action of 5 α-reductase. Type I is the controlling isoenzyme. This study describes a 3-month, multicenter, randomized, placebo-controlled clinical trial with a potent, selective inhibitor of type I 5 α-reductase used alone and in combination with systemic minocycline. Inhibition of type I 5 α-reductase was not associated with clinical improvement of acne when used alone and did not enhance the clinical benefit of systemic minocycline. These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume50
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Acne Vulgaris
Sebaceous Glands
Oxidoreductases
Minocycline
Androgens
Sebum
Dihydrotestosterone
Isoenzymes
Therapeutics
Randomized Controlled Trials
Placebos

ASJC Scopus subject areas

  • Dermatology

Cite this

Leyden, J., Bergfeld, W., Drake, L., Dunlap, F., Goldman, M. P., Gottlieb, A. B., ... Waldstreicher, J. (2004). A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris. Journal of the American Academy of Dermatology, 50(3), 443-447. https://doi.org/10.1016/j.jaad.2003.07.021

A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris. / Leyden, James; Bergfeld, Wilma; Drake, Lynn; Dunlap, Frank; Goldman, Mitchel P.; Gottlieb, Alice B.; Heffernan, Michael P.; Hickman, Janet G.; Hordinsky, Maria; Jarrett, Michael; Kang, Sewon; Lucky, Ann; Peck, Gary; Phillips, Tania; Rapaport, Marvin; Roberts, Janet; Savin, Ronald; Sawaya, Marty E.; Shalita, Alan; Shavin, Joel; Shaw, James C.; Stein, Linda; Stewart, Daniel; Strauss, John; Swinehart, James; Swinyer, Leonard; Thiboutot, Diane; Washenik, Ken; Weinstein, Gerald; Whiting, David; Pappas, Frances; Sanchez, Matilde; Terranella, Lisa; Waldstreicher, Joanne.

In: Journal of the American Academy of Dermatology, Vol. 50, No. 3, 03.2004, p. 443-447.

Research output: Contribution to journalArticle

Leyden, J, Bergfeld, W, Drake, L, Dunlap, F, Goldman, MP, Gottlieb, AB, Heffernan, MP, Hickman, JG, Hordinsky, M, Jarrett, M, Kang, S, Lucky, A, Peck, G, Phillips, T, Rapaport, M, Roberts, J, Savin, R, Sawaya, ME, Shalita, A, Shavin, J, Shaw, JC, Stein, L, Stewart, D, Strauss, J, Swinehart, J, Swinyer, L, Thiboutot, D, Washenik, K, Weinstein, G, Whiting, D, Pappas, F, Sanchez, M, Terranella, L & Waldstreicher, J 2004, 'A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris', Journal of the American Academy of Dermatology, vol. 50, no. 3, pp. 443-447. https://doi.org/10.1016/j.jaad.2003.07.021
Leyden, James ; Bergfeld, Wilma ; Drake, Lynn ; Dunlap, Frank ; Goldman, Mitchel P. ; Gottlieb, Alice B. ; Heffernan, Michael P. ; Hickman, Janet G. ; Hordinsky, Maria ; Jarrett, Michael ; Kang, Sewon ; Lucky, Ann ; Peck, Gary ; Phillips, Tania ; Rapaport, Marvin ; Roberts, Janet ; Savin, Ronald ; Sawaya, Marty E. ; Shalita, Alan ; Shavin, Joel ; Shaw, James C. ; Stein, Linda ; Stewart, Daniel ; Strauss, John ; Swinehart, James ; Swinyer, Leonard ; Thiboutot, Diane ; Washenik, Ken ; Weinstein, Gerald ; Whiting, David ; Pappas, Frances ; Sanchez, Matilde ; Terranella, Lisa ; Waldstreicher, Joanne. / A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris. In: Journal of the American Academy of Dermatology. 2004 ; Vol. 50, No. 3. pp. 443-447.
@article{ecb99fc53e7847ffaa00a8352b31e08f,
title = "A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris",
abstract = "Excessive sebum production is a central aspect of the pathophysiology of acne vulgaris. Sebaceous gland function is under androgen control and it is hypothesized that dihydrotestosterone is formed by the action of 5 α-reductase. Type I is the controlling isoenzyme. This study describes a 3-month, multicenter, randomized, placebo-controlled clinical trial with a potent, selective inhibitor of type I 5 α-reductase used alone and in combination with systemic minocycline. Inhibition of type I 5 α-reductase was not associated with clinical improvement of acne when used alone and did not enhance the clinical benefit of systemic minocycline. These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function.",
author = "James Leyden and Wilma Bergfeld and Lynn Drake and Frank Dunlap and Goldman, {Mitchel P.} and Gottlieb, {Alice B.} and Heffernan, {Michael P.} and Hickman, {Janet G.} and Maria Hordinsky and Michael Jarrett and Sewon Kang and Ann Lucky and Gary Peck and Tania Phillips and Marvin Rapaport and Janet Roberts and Ronald Savin and Sawaya, {Marty E.} and Alan Shalita and Joel Shavin and Shaw, {James C.} and Linda Stein and Daniel Stewart and John Strauss and James Swinehart and Leonard Swinyer and Diane Thiboutot and Ken Washenik and Gerald Weinstein and David Whiting and Frances Pappas and Matilde Sanchez and Lisa Terranella and Joanne Waldstreicher",
year = "2004",
month = "3",
doi = "10.1016/j.jaad.2003.07.021",
language = "English (US)",
volume = "50",
pages = "443--447",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris

AU - Leyden, James

AU - Bergfeld, Wilma

AU - Drake, Lynn

AU - Dunlap, Frank

AU - Goldman, Mitchel P.

AU - Gottlieb, Alice B.

AU - Heffernan, Michael P.

AU - Hickman, Janet G.

AU - Hordinsky, Maria

AU - Jarrett, Michael

AU - Kang, Sewon

AU - Lucky, Ann

AU - Peck, Gary

AU - Phillips, Tania

AU - Rapaport, Marvin

AU - Roberts, Janet

AU - Savin, Ronald

AU - Sawaya, Marty E.

AU - Shalita, Alan

AU - Shavin, Joel

AU - Shaw, James C.

AU - Stein, Linda

AU - Stewart, Daniel

AU - Strauss, John

AU - Swinehart, James

AU - Swinyer, Leonard

AU - Thiboutot, Diane

AU - Washenik, Ken

AU - Weinstein, Gerald

AU - Whiting, David

AU - Pappas, Frances

AU - Sanchez, Matilde

AU - Terranella, Lisa

AU - Waldstreicher, Joanne

PY - 2004/3

Y1 - 2004/3

N2 - Excessive sebum production is a central aspect of the pathophysiology of acne vulgaris. Sebaceous gland function is under androgen control and it is hypothesized that dihydrotestosterone is formed by the action of 5 α-reductase. Type I is the controlling isoenzyme. This study describes a 3-month, multicenter, randomized, placebo-controlled clinical trial with a potent, selective inhibitor of type I 5 α-reductase used alone and in combination with systemic minocycline. Inhibition of type I 5 α-reductase was not associated with clinical improvement of acne when used alone and did not enhance the clinical benefit of systemic minocycline. These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function.

AB - Excessive sebum production is a central aspect of the pathophysiology of acne vulgaris. Sebaceous gland function is under androgen control and it is hypothesized that dihydrotestosterone is formed by the action of 5 α-reductase. Type I is the controlling isoenzyme. This study describes a 3-month, multicenter, randomized, placebo-controlled clinical trial with a potent, selective inhibitor of type I 5 α-reductase used alone and in combination with systemic minocycline. Inhibition of type I 5 α-reductase was not associated with clinical improvement of acne when used alone and did not enhance the clinical benefit of systemic minocycline. These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function.

UR - http://www.scopus.com/inward/record.url?scp=12144288631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144288631&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2003.07.021

DO - 10.1016/j.jaad.2003.07.021

M3 - Article

C2 - 14988688

AN - SCOPUS:12144288631

VL - 50

SP - 443

EP - 447

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -