A systematic review of the associations between HIV/HCV coinfection and biomarkers of cardiovascular disease

Olatokunbo Osibogun, Oluseye Ogunmoroti, Erin Donnelly Michos, Erica S. Spatz, Babatunde Olubajo, Khurram Nasir, Wasim Maziak

Research output: Contribution to journalArticle

Abstract

Summary: The incidence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection has been increasing with over 10 million people affected globally. The role biomarkers play as predictors of cardiovascular disease (CVD) risk among coinfected individuals is not well defined. We aimed to systematically review current evidence describing CVD biomarkers among individuals with HIV/HCV coinfection. We searched EMBASE, CINAHL, Google Scholar, PubMed, and Web of Science from inception to June 2017. MeSH terms and keywords were used to identify studies with information on HIV/HCV coinfection and CVD biomarkers (structural, functional, and serological) such as carotid intima-media thickness (CIMT), endothelial markers, C-reactive protein (CRP), homocysteine, and lipids. Among 332 articles screened, 28 were included (39,498 participants). Study designs varied: 18 cross-sectional, 9 cohort, and 1 clinical trial. Compared with healthy controls and people with HIV or HCV monoinfection, individuals with HIV/HCV coinfection had statistically significant lower levels of lipids and CRP and higher levels of endothelial markers (sICAM-1 and sVCAM-1), CIMT, homocysteine, and IL-6. One study found the odds of carotid plaque in coinfected individuals was 1.64 (0.91-2.94) compared with healthy controls, and another study showed the prevalence of vascular plaques (carotid and femoral) in coinfected individuals was higher compared with HIV monoinfected individuals (44% vs 14%, P = 0.04). Biomarkers of CVD have different patterns of association with HIV/HCV coinfection compared with monoinfection and healthy controls. Prospective studies are needed to confirm the predictive value of these biomarkers for clinical CVD risk among coinfected individuals.

Original languageEnglish (US)
JournalReviews in Medical Virology
DOIs
StateAccepted/In press - Jan 1 2017

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Coinfection
Hepacivirus
Cardiovascular Diseases
Biomarkers
HIV
Carotid Intima-Media Thickness
Homocysteine
C-Reactive Protein
Lipids
Virus Diseases
Thigh
PubMed
Blood Vessels
Interleukin-6
Cross-Sectional Studies
Clinical Trials
Prospective Studies
Incidence

Keywords

  • Biomarkers
  • Cardiovascular disease
  • HIV/HCV coinfection
  • Systematic review

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

A systematic review of the associations between HIV/HCV coinfection and biomarkers of cardiovascular disease. / Osibogun, Olatokunbo; Ogunmoroti, Oluseye; Michos, Erin Donnelly; Spatz, Erica S.; Olubajo, Babatunde; Nasir, Khurram; Maziak, Wasim.

In: Reviews in Medical Virology, 01.01.2017.

Research output: Contribution to journalArticle

Osibogun, Olatokunbo ; Ogunmoroti, Oluseye ; Michos, Erin Donnelly ; Spatz, Erica S. ; Olubajo, Babatunde ; Nasir, Khurram ; Maziak, Wasim. / A systematic review of the associations between HIV/HCV coinfection and biomarkers of cardiovascular disease. In: Reviews in Medical Virology. 2017.
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