A systematic review of rapid drug susceptibility tests for multidrug-resistant tuberculosis using rifampin resistance as a surrogate

Kwok Chiu Chang, Wing Wai Yew, Ying Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: The emergence of multidrug-resistant tuberculosis (MDR-TB) has prompted the development of rapid drug susceptibility assays with a focus on rifampin in recent years. Systematic reviews with evaluation of predictive values for different assays are scarce. Method: MEDLINE was searched on 6 September 2008 for English articles that contain concurrent original data for generating summary measures of sensitivity, specificity and likelihood ratios of rapid rifampin susceptibility assays. Results/conclusions: Significant heterogeneity was found in likelihood ratios across studies of all assays except nitrate reductase assay and colorimetric assays. Although rapid assays are fairly reliable for ruling out MDR-TB, careful consideration of clinical risk factors is required before using these assays to rule in MDR-TB under different epidemiological settings.

Original languageEnglish (US)
Pages (from-to)99-122
Number of pages24
JournalExpert Opinion on Medical Diagnostics
Volume3
Issue number2
DOIs
StatePublished - Mar 2009

Keywords

  • Meta-analysis
  • Multidrug-resistant
  • Rifampin
  • Susceptibility
  • Tuberculosis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Medicine
  • Biochemistry, medical

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