A systematic review of imaging studies of human brown adipose tissue

Prasanna Santhanam; Steven P. Rowe; Lilja B. Solnes; Brittany Quainoo; Rexford S. Ahima

doi:10.1111/nyas.14579

A systematic review of imaging studies of human brown adipose tissue

Prasanna Santhanam, Steven P. Rowe, Lilja B. Solnes, Brittany Quainoo, Rexford S. Ahima

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high-resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single-photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.

Original language	English (US)
Pages (from-to)	5-23
Number of pages	19
Journal	Annals of the New York Academy of Sciences
Volume	1495
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14579
State	Published - 2021

Keywords

BAT
CT
FDG
MRI
PET
brown adipose tissue

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.14579

Cite this

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title = "A systematic review of imaging studies of human brown adipose tissue",

abstract = "Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2-deoxy-2-[18F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high-resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single-photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.",

keywords = "BAT, CT, FDG, MRI, PET, brown adipose tissue",

author = "Prasanna Santhanam and Rowe, {Steven P.} and Solnes, {Lilja B.} and Brittany Quainoo and Ahima, {Rexford S.}",

note = "Funding Information: This work was supported in part by a Bloomberg Professorship to R.S.A. We are also very appreciative of Ms. Katie Lobner from the Johns Hopkins School of Medicine Welch Informationist Services. Publisher Copyright: {\textcopyright} 2021 New York Academy of Sciences.",

year = "2021",

doi = "10.1111/nyas.14579",

language = "English (US)",

volume = "1495",

pages = "5--23",

journal = "Annals of the New York Academy of Sciences",

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AU - Santhanam, Prasanna

AU - Rowe, Steven P.

AU - Solnes, Lilja B.

AU - Quainoo, Brittany

AU - Ahima, Rexford S.

N1 - Funding Information: This work was supported in part by a Bloomberg Professorship to R.S.A. We are also very appreciative of Ms. Katie Lobner from the Johns Hopkins School of Medicine Welch Informationist Services. Publisher Copyright: © 2021 New York Academy of Sciences.

PY - 2021

Y1 - 2021

N2 - Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2-deoxy-2-[18F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high-resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single-photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.

AB - Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2-deoxy-2-[18F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high-resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single-photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.

KW - BAT

KW - CT

KW - FDG

KW - MRI

KW - PET

KW - brown adipose tissue

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M3 - Review article

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A systematic review of imaging studies of human brown adipose tissue

Abstract

Keywords

ASJC Scopus subject areas

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