A synergistic relationship of elevated low-density lipoprotein cholesterol levels and systolic blood pressure with coronary artery calcification

Kiran Musunuru, Khurram Nasir, Shivda Pandey, Catherine C. Campbell, Jose A M Carvalho, Romeu Meneghello, Matthew J. Budoff, Roger S Blumenthal, Raul D. Santos

Research output: Contribution to journalArticle

Abstract

We sought to evaluate this "response-to-injury" hypothesis of atherosclerosis by studying the interaction between systolic blood pressure (SBP) and LDL- cholesterol (LDL-C) in predicting the presence of coronary artery calcification (CAC) in asymptomatic men. We studied 526 men (46 ± 7 years of age) referred for electron-beam tomography (EBT) exam. The prevalence of CAC was determined across LDL-C tertiles (low:

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalAtherosclerosis
Volume200
Issue number2
DOIs
StatePublished - Oct 2008

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LDL Cholesterol
Coronary Vessels
Blood Pressure
X Ray Computed Tomography
Atherosclerosis
Wounds and Injuries
low density lipoprotein inhibitor

Keywords

  • Coronary calcification
  • Electron beam tomography
  • LDL-cholesterol
  • Risk factors
  • Subclinical atherosclerosis
  • Systolic blood pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A synergistic relationship of elevated low-density lipoprotein cholesterol levels and systolic blood pressure with coronary artery calcification. / Musunuru, Kiran; Nasir, Khurram; Pandey, Shivda; Campbell, Catherine C.; Carvalho, Jose A M; Meneghello, Romeu; Budoff, Matthew J.; Blumenthal, Roger S; Santos, Raul D.

In: Atherosclerosis, Vol. 200, No. 2, 10.2008, p. 368-373.

Research output: Contribution to journalArticle

Musunuru, Kiran ; Nasir, Khurram ; Pandey, Shivda ; Campbell, Catherine C. ; Carvalho, Jose A M ; Meneghello, Romeu ; Budoff, Matthew J. ; Blumenthal, Roger S ; Santos, Raul D. / A synergistic relationship of elevated low-density lipoprotein cholesterol levels and systolic blood pressure with coronary artery calcification. In: Atherosclerosis. 2008 ; Vol. 200, No. 2. pp. 368-373.
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