A survey of the utilization of anti-pseudomonal beta-lactam therapy in cystic fibrosis patients

Jeffery T. Zobell, David C. Young, C. Dustin Waters, Krow Ampofo, Jared Cash, Bruce C. Marshall, Jared Olson, Barbara A. Chatfield

Research output: Contribution to journalReview articlepeer-review

Abstract

The purpose of this study was to characterize the utilization of anti-pseudomonal beta-lactam antibiotics in the treatment of acute pulmonary exacerbations (APE) among Cystic Fibrosis Foundation (CFF)-accredited care centers. An anonymous national cross-sectional survey of CFF-accredited care centers was performed using an electronic survey tool (SurveyMonkey.com®). One hundred and twenty-one of 261 centers completed the survey (46%) representing 56% (14,856/26,740) of patients in the CFF Patient Registry. One hundred and nineteen of 121 (98%) respondents reported using beta-lactams for the treatment of APE. Intermittent dosing regimens constituted 155/167 (93%) reported regimens, while extended infusions were 12/167 (7%). Ceftazidime was the most commonly utilized beta-lactam comprising 74/167 (44%) of all infusions (intermittent and extended) of which 70/74 (95%) were intermittent infusions. The majority of intermittent ceftazidime regimens (56/70; 80%) were at doses lower than CFF and European guidelines recommended doses. In conclusion, a great majority of respondents use intermittent anti-pseudomonal beta-lactam antibiotics, with over half of respondents utilizing lower than guidelines recommended doses. While this is of concern, it is not known if optimization of dosing strategies according to guidelines recommendations will result in clinical benefit.

Original languageEnglish (US)
Pages (from-to)987-990
Number of pages4
JournalPediatric pulmonology
Volume46
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Pseudomonas aeruginosa
  • antibiotics
  • pulmonary exacerbations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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