A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease

S. P. Staal, Richard F Ambinder, W. E. Beschorner, Gary Selwyn Hayward, R. Mann

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A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalAmerican Journal of Clinical Pathology
Issue number1
Publication statusPublished - 1989


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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