A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease

S. P. Staal; R. Ambinder; W. E. Beschorner; G. S. Hayward; R. Mann

doi:10.1093/ajcp/91.1.1

A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease

S. P. Staal, R. Ambinder, W. E. Beschorner, G. S. Hayward, R. Mann

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	American journal of clinical pathology
Volume	91
Issue number	1
DOIs	https://doi.org/10.1093/ajcp/91.1.1
State	Published - 1989

ASJC Scopus subject areas

Pathology and Forensic Medicine

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abstract = "A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.",

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AU - Hayward, G. S.

AU - Mann, R.

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