Abstract
A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | American Journal of Clinical Pathology |
| Volume | 91 |
| Issue number | 1 |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease. / Staal, S. P.; Ambinder, Richard F; Beschorner, W. E.; Hayward, Gary Selwyn; Mann, R.
In: American Journal of Clinical Pathology, Vol. 91, No. 1, 1989, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease
AU - Staal, S. P.
AU - Ambinder, Richard F
AU - Beschorner, W. E.
AU - Hayward, Gary Selwyn
AU - Mann, R.
PY - 1989
Y1 - 1989
N2 - A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.
AB - A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024592069&partnerID=8YFLogxK
M3 - Article
C2 - 2535912
AN - SCOPUS:0024592069
VL - 91
SP - 1
EP - 5
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 1
ER -