A super-resolution feasibility study in small animal SPECT imaging

José L. Villena, Eduardo Lage, Alvaro De Carlos, Gustavo Tapias, Alejandro Sisniega, Juan José Vaquero, Manuel Desco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lack of spatial resolution is a major drawback in small-animal SPECT imaging, particularly when parallel hole collimators are employed. This work evaluates the feasibility of enhancing the spatial resolution of a small-animal SPECT scanner by applying an approach based on a super-resolution technique combined with dedicated hardware. The detectors are based on PS-PMTs (Hamamatsu, H8500), NaI(TI) crystal arrays and parallel hole collimators. The system enables the mechanical shifting of the gamma-cameras and the object under study during the acquisition in steps smaller than the detector intrinsic sampling pitch. This fact allows using a super-resolution technique without the necessity of blind movement estimators between projections. In the absence of noise the algorithm converged to the original image, and with real noisy data it achieved improvements in resolution between 28% (tomographic) and 42% (planar) in phantom studies.

Original languageEnglish (US)
Title of host publication2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages4755-4759
Number of pages5
DOIs
StatePublished - Dec 1 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Villena, J. L., Lage, E., De Carlos, A., Tapias, G., Sisniega, A., Vaquero, J. J., & Desco, M. (2008). A super-resolution feasibility study in small animal SPECT imaging. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 4755-4759). [4774306] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774306