A subset of small nuclear ribonucleoprotein particle antigens is a component of the nuclear matrix

Bert Vogelstein, Brett F. Hunt

Research output: Contribution to journalArticlepeer-review

Abstract

We have assessed whether antigenic proteins associated with small nuclear ribonucleoprotein particles (snRNP) are associated with the nuclear matrix. Immunofluorescence studies showed that a subset of these particles (those reactive with anti-Sm antisera) were associated with the nuclear matrix, while a different set of particles (those reactive with anti-La antisera) were not associated with the nuclear matrix. Immunoprecipitation experiments showed that three specific polypeptide components of the snRNP reactive with the anti-Sm antisera were significantly enriched in nuclear matrix proteins.

Original languageEnglish (US)
Pages (from-to)1224-1232
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume105
Issue number3
DOIs
StatePublished - Apr 14 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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