A subset of small nuclear ribonucleoprotein particle antigens is a component of the nuclear matrix

Bert Vogelstein; Brett F. Hunt

doi:10.1016/0006-291X(82)91099-3

A subset of small nuclear ribonucleoprotein particle antigens is a component of the nuclear matrix

Bert Vogelstein, Brett F. Hunt

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We have assessed whether antigenic proteins associated with small nuclear ribonucleoprotein particles (snRNP) are associated with the nuclear matrix. Immunofluorescence studies showed that a subset of these particles (those reactive with anti-Sm antisera) were associated with the nuclear matrix, while a different set of particles (those reactive with anti-La antisera) were not associated with the nuclear matrix. Immunoprecipitation experiments showed that three specific polypeptide components of the snRNP reactive with the anti-Sm antisera were significantly enriched in nuclear matrix proteins.

Original language	English (US)
Pages (from-to)	1224-1232
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	105
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(82)91099-3
State	Published - Apr 14 1982

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "We have assessed whether antigenic proteins associated with small nuclear ribonucleoprotein particles (snRNP) are associated with the nuclear matrix. Immunofluorescence studies showed that a subset of these particles (those reactive with anti-Sm antisera) were associated with the nuclear matrix, while a different set of particles (those reactive with anti-La antisera) were not associated with the nuclear matrix. Immunoprecipitation experiments showed that three specific polypeptide components of the snRNP reactive with the anti-Sm antisera were significantly enriched in nuclear matrix proteins.",

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AB - We have assessed whether antigenic proteins associated with small nuclear ribonucleoprotein particles (snRNP) are associated with the nuclear matrix. Immunofluorescence studies showed that a subset of these particles (those reactive with anti-Sm antisera) were associated with the nuclear matrix, while a different set of particles (those reactive with anti-La antisera) were not associated with the nuclear matrix. Immunoprecipitation experiments showed that three specific polypeptide components of the snRNP reactive with the anti-Sm antisera were significantly enriched in nuclear matrix proteins.

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