A study of potential vestibulotoxic effects of once daily versus thrice daily administration of tobramycin

Leonard Proctor, Brent Petty, Ruchtra Thakor, Paul Lietman, Robert Glackin, Hiroshi Shimizu

Research output: Contribution to journalArticlepeer-review

Abstract

Tobramycin 5.1 mg/kg/day was administered for 9 days to 20 healthy human volunteers to determine the potential vestibulotoxicity of once daily versus thrice daily treatment regimens. Vestibular function was tested carefully before, during, and following drug administration, using a battery of postural and caloric tests. Although subjects receiving the once daily regimen performed better on the postural tests, we feel this does not necessarily indicate an adverse effect in either group. The caloric test was the primary measure of vestibular function in this experiment, and this test appeared to demonstrate a slight adverse effect during drug administration of equal magnitude in both treatment groups. The results of this experiment indicate that there is no significant difference in the risk of adverse vestibular effects between once daily and thrice daily tobramycin administration.

Original languageEnglish (US)
Pages (from-to)1443-1449
Number of pages7
JournalLaryngoscope
Volume97
Issue number12
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Otorhinolaryngology

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