TY - JOUR
T1 - A study of aminoglutethemide and hydrocortisone in patients with advanced and refractory prostate carcinoma
AU - Chang, A. Y.C.
AU - Bennett, J. M.
AU - Pandya, K. J.
AU - Asbury, R.
AU - McCune, C.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - We have studied aminoglutethemide (AG) combined with hydrocortisone in 28 patients with advanced and refractory prostate carcinoma. All the patients had failed at least one endocrine therapy. Six patients received only one prior hormonal treatment. Five patients were off study within 3 weeks due to early death and toxicity, 14 had progressive disease, and 9 had stable disease. No objective partial remission was observed, but the nine stable patients had therapeutic benefit, with improvement in bone pain and performance status for a median duration of 153 days. Three patients withdrew because of postural hypotension, dizziness, weakness, and lethargy. The median survival of the entire group was 186 days (range 41-606 days). Our results suggest that aminoglutethemide and hydrocortisone can be alternative treatment for patients with advanced and refractory prostate carcinoma.
AB - We have studied aminoglutethemide (AG) combined with hydrocortisone in 28 patients with advanced and refractory prostate carcinoma. All the patients had failed at least one endocrine therapy. Six patients received only one prior hormonal treatment. Five patients were off study within 3 weeks due to early death and toxicity, 14 had progressive disease, and 9 had stable disease. No objective partial remission was observed, but the nine stable patients had therapeutic benefit, with improvement in bone pain and performance status for a median duration of 153 days. Three patients withdrew because of postural hypotension, dizziness, weakness, and lethargy. The median survival of the entire group was 186 days (range 41-606 days). Our results suggest that aminoglutethemide and hydrocortisone can be alternative treatment for patients with advanced and refractory prostate carcinoma.
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U2 - 10.1097/00000421-198908000-00017
DO - 10.1097/00000421-198908000-00017
M3 - Article
C2 - 2474242
AN - SCOPUS:0024409398
SN - 0277-3732
VL - 12
SP - 358
EP - 360
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 4
ER -