A structural view of CD4 and CD8

D. J. Leahy

Research output: Contribution to journalArticle

Abstract

CD4 and CD8 are cell-surface glycoproteins that participate in molecular complexes involved in both T cell development and antigen recognition by T cells. CD4 and CD8 interact with nonpolymorphic regions of class II and class I major histocompatibility complex (MHC) molecules, respectively, and these interactions result in increased intercellular adhesion and enhanced stimulation of T cells. A src-like tyrosine kinase, p56(lck), is associated with the cytoplasmic domain of both CD4 and CD8 and may be involved in transmembrane signaling. Crystal structures of extracellular regions of CD4 and CD8 have been determined and have provided a basis for understanding and probing CD4 and CD8 function. The structures of CD4 and CD8 are reviewed here, along with the implications of these structures for CD4 and CD8 function.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalFASEB Journal
Volume9
Issue number1
StatePublished - 1995

Fingerprint

T-cells
T-lymphocytes
T-Lymphocytes
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
src-Family Kinases
Viral Tumor Antigens
Membrane Glycoproteins
major histocompatibility complex
crystal structure
Major Histocompatibility Complex
Protein-Tyrosine Kinases
adhesion
tyrosine
glycoproteins
phosphotransferases (kinases)
Adhesion
Crystal structure
antigens
Antigens
Molecules

Keywords

  • coreceptor
  • glycoprotein
  • structure
  • T cell

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Leahy, D. J. (1995). A structural view of CD4 and CD8. FASEB Journal, 9(1), 17-25.

A structural view of CD4 and CD8. / Leahy, D. J.

In: FASEB Journal, Vol. 9, No. 1, 1995, p. 17-25.

Research output: Contribution to journalArticle

Leahy, DJ 1995, 'A structural view of CD4 and CD8', FASEB Journal, vol. 9, no. 1, pp. 17-25.
Leahy DJ. A structural view of CD4 and CD8. FASEB Journal. 1995;9(1):17-25.
Leahy, D. J. / A structural view of CD4 and CD8. In: FASEB Journal. 1995 ; Vol. 9, No. 1. pp. 17-25.
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