Abstract
A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca2+ within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca2+-calcineurin signaling, nutrient sensing and regulation of the cell cycle.
Original language | English (US) |
---|---|
Pages (from-to) | 870-873 |
Number of pages | 4 |
Journal | Cell Cycle |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2008 |
Keywords
- Antifungal
- Calcineurin
- Calcium signaling
- Cell cycle
- MAP kinase
- Swe1
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology