A spoke in the wheel: Calcium spikes disrupt yeast cell cycle

Yong Qiang Zhang, Rajini Rao

Research output: Contribution to journalReview articlepeer-review

Abstract

A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca2+ within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca2+-calcineurin signaling, nutrient sensing and regulation of the cell cycle.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalCell Cycle
Volume7
Issue number7
DOIs
StatePublished - Apr 1 2008

Keywords

  • Antifungal
  • Calcineurin
  • Calcium signaling
  • Cell cycle
  • MAP kinase
  • Swe1

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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