A SPECT scanner for rodent imaging based on small-area gamma cameras

Eduardo Lage, José L. Villena, Gustavo Tapias, Naira P. Martínez, Maria L. Soto-Montenegro, Mónica Abella, Alejandro Sisniega, Francisco Pino, Domènec Ros, Javier Pavía, Manuel Desco, Juan J. Vaquero

Research output: Contribution to journalArticlepeer-review

Abstract

We developed a cost-effective SPECT scanner prototype (rSPECT) for in vivo imaging of rodents based on small-area gamma cameras. Each detector consists of a position-sensitive photomultiplier tube (PS-PMT) coupled to a 30 × 30 NaI(Tl) scintillator array and electronics attached to the PS-PMT sockets for adapting the detector signals to an in-house developed data acquisition system. The detector components are enclosed in a lead-shielded case with a receptacle to insert the collimators. System performance was assessed using 99m Tc for a high-resolution parallel-hole collimator, and for a 0.75-mm pinhole collimator with a 60° aperture angle and a 42-mm collimator length. The energy resolution is about 10.7% of the photopeak energy. The overall system sensitivity is about 3 cps/μ Ci/detector and planar spatial resolution ranges from 2.4 mm at 1 cm source-to-collimator distance to 4.1 mm at 4.5 cm with parallel-hole collimators. With pinhole collimators planar spatial resolution ranges from 1.2 mm at 1 cm source-to-collimator distance to 2.4 mm at 4.5 cm; sensitivity at these distances ranges from 2.8 to 0.5 cps/μ Ci/detector. Tomographic hot-rod phantom images are presented together with images of bone, myocardium and brain of living rodents to demonstrate the feasibility of preclinical small-animal studies with the rSPECT.

Original languageEnglish (US)
Article number5571005
Pages (from-to)2524-2531
Number of pages8
JournalIEEE Transactions on Nuclear Science
Volume57
Issue number5 PART 1
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Single Photon Emission Computed Tomography (SPECT)
  • small-animal imaging
  • small-area gamma camera

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

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