A specimen volume of ≥80 mL improves cytologic sensitivity for malignant ascites: A retrospective analysis of 2665 cases

Lisa Rooper, Syed Z Ali, Matthew T. Olson

Research output: Contribution to journalArticle

Abstract

Introduction: Although paracentesis simultaneously allows cytologic evaluation of peritoneal fluid and symptomatic relief, its utility is limited by a paltry 50% to 60% sensitivity for malignancy. Specimen volume has recently been shown to affect cytologic diagnosis in other body fluids, but its role has never been examined in ascites. This study evaluates how specimen volume impacts cytologic diagnosis of malignant ascites. Materials and methods: We identified 2665 consecutive paracentesis specimens with documented numeric volumes collected at our institution between 1994 and 2013. We separated the cases into 10 bins of roughly equivalent sample size and compared the percentage of cases that received malignant diagnoses across each cutoff volume. When follow-up pathology was available, we also compared the sensitivity of cytology with the gold standard of surgical pathology. Results: The peritoneal fluids had a mean volume of 760.2 mL (range: 1-10,000). Just 11.3% of specimens with volumes

Original languageEnglish (US)
JournalJournal of the American Society of Cytopathology
DOIs
StateAccepted/In press - Feb 16 2016

Keywords

  • Ascitic fluid/cytology
  • Ascitic fluid/pathology
  • Cytological techniques/methods
  • Peritoneal neoplasms/diagnosis
  • Peritoneum/cytology
  • Peritoneum/pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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