A sparse covarying unit that describes healthy and impaired human gut microbiota development

Arjun S. Raman, Jeanette L. Gehrig, Siddarth Venkatesh, Hao Wei Chang, Matthew C. Hibberd, Sathish Subramanian, Gagandeep Kang, Pascal O. Bessong, Aldo A.M. Lima, Margaret N. Kosek, William A. Petri, Dmitry A. Rodionov, Aleksandr A. Arzamasov, Semen A. Leyn, Andrei L. Osterman, Sayeeda Huq, Ishita Mostafa, Munirul Islam, Mustafa Mahfuz, Rashidul HaqueTahmeed Ahmed, Michael J. Barratt, Jeffrey I. Gordon

Research output: Contribution to journalArticle

Abstract

Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbiota of healthy members of a Bangladeshi birth cohort sampled from 1 to 60 months of age. The results revealed an “ecogroup” of 15 covarying bacterial taxa that provide a concise description of microbiota development in healthy children from this and other low-income countries, and a means for monitoring community repair in undernourished children treated with therapeutic foods. Features of ecogroup population dynamics were recapitulated in gnotobiotic piglets as they transitioned from exclusive milk feeding to a fully weaned state consuming a representative Bangladeshi diet.

Original languageEnglish (US)
Article numberY
JournalScience
Volume365
Issue number6449
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • General

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    Raman, A. S., Gehrig, J. L., Venkatesh, S., Chang, H. W., Hibberd, M. C., Subramanian, S., Kang, G., Bessong, P. O., Lima, A. A. M., Kosek, M. N., Petri, W. A., Rodionov, D. A., Arzamasov, A. A., Leyn, S. A., Osterman, A. L., Huq, S., Mostafa, I., Islam, M., Mahfuz, M., ... Gordon, J. I. (2019). A sparse covarying unit that describes healthy and impaired human gut microbiota development. Science, 365(6449), [Y]. https://doi.org/10.1126/science.aau4735