A snapshot of tissue glycerolipids

Amina S. Woods, Hay Yan J Wang, Shelley N. Jackson

Research output: Contribution to journalArticle

Abstract

The lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intracellular one's main components are negatively charged. Advances in mass spectrometry have allowed the direct probing of tissues, and thus a direct approach to probing membranes make up was developed. Until recently most studies have focused on proteins. An overview of the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) for the direct analysis of phospholipids in various tissue is presented. Molecular ions corresponding to phosphatidylcholines, sphingomyelin, phosphatidylethanolamines, phosphatidylserines, phosphatidylinositols and sulfatides were mapped.

Original languageEnglish (US)
Pages (from-to)3344-3356
Number of pages13
JournalCurrent Pharmaceutical Design
Volume13
Issue number32
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Mass Spectrometry
Phosphatidylethanolamines
Sulfoglycosphingolipids
Glycerophospholipids
Sphingomyelins
Phosphatidylserines
Glycolipids
Membrane Lipids
Phosphatidylinositols
Phosphatidylcholines
Phospholipids
Lasers
Cell Membrane
Ions
Membranes
Proteins
Protect-It

Keywords

  • Lipid
  • MALDI
  • Phosphatidylethanolamines
  • Phosphocholine head group
  • Ragment peaks

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Woods, A. S., Wang, H. Y. J., & Jackson, S. N. (2007). A snapshot of tissue glycerolipids. Current Pharmaceutical Design, 13(32), 3344-3356. https://doi.org/10.2174/138161207782360636

A snapshot of tissue glycerolipids. / Woods, Amina S.; Wang, Hay Yan J; Jackson, Shelley N.

In: Current Pharmaceutical Design, Vol. 13, No. 32, 11.2007, p. 3344-3356.

Research output: Contribution to journalArticle

Woods, AS, Wang, HYJ & Jackson, SN 2007, 'A snapshot of tissue glycerolipids', Current Pharmaceutical Design, vol. 13, no. 32, pp. 3344-3356. https://doi.org/10.2174/138161207782360636
Woods, Amina S. ; Wang, Hay Yan J ; Jackson, Shelley N. / A snapshot of tissue glycerolipids. In: Current Pharmaceutical Design. 2007 ; Vol. 13, No. 32. pp. 3344-3356.
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