A snapshot of tissue glycerolipids

Amina S. Woods, Hay Yan J Wang, Shelley N. Jackson

Research output: Contribution to journalArticle

Abstract

The lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intracellular one's main components are negatively charged. Advances in mass spectrometry have allowed the direct probing of tissues, and thus a direct approach to probing membranes make up was developed. Until recently most studies have focused on proteins. An overview of the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) for the direct analysis of phospholipids in various tissue is presented. Molecular ions corresponding to phosphatidylcholines, sphingomyelin, phosphatidylethanolamines, phosphatidylserines, phosphatidylinositols and sulfatides were mapped.

Original languageEnglish (US)
Pages (from-to)3344-3356
Number of pages13
JournalCurrent Pharmaceutical Design
Volume13
Issue number32
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Lipid
  • MALDI
  • Phosphatidylethanolamines
  • Phosphocholine head group
  • Ragment peaks

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Woods, A. S., Wang, H. Y. J., & Jackson, S. N. (2007). A snapshot of tissue glycerolipids. Current Pharmaceutical Design, 13(32), 3344-3356. https://doi.org/10.2174/138161207782360636