A single adeno-associated virus (AAV)-murine factor VIII vector partially corrects the hemophilia A phenotype

R. Sarkar, W. Xiaoy, H. H. Kazazian

Research output: Contribution to journalArticle

Abstract

A major obstacle for delivery of factor (F)VIII using adeno-associated virus (AAV) vectors is the large size of FVIII cDNA, which is well above the 5 kb packaging limit for AAV. Here we construct a

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume1
Issue number2
DOIs
StatePublished - Feb 2003
Externally publishedYes

Fingerprint

Dependovirus
Factor VIII
Hemophilia A
Phenotype
Product Packaging
Complementary DNA

Keywords

  • AAV-2
  • Hemophilia A
  • Murine factor VIII
  • Single vector

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

A single adeno-associated virus (AAV)-murine factor VIII vector partially corrects the hemophilia A phenotype. / Sarkar, R.; Xiaoy, W.; Kazazian, H. H.

In: Journal of Thrombosis and Haemostasis, Vol. 1, No. 2, 02.2003, p. 220-226.

Research output: Contribution to journalArticle

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