A simultaneous multi-slice selective J-resolved experiment for fully resolved scalar coupling information

Qing Zeng, Liangjie Lin, Jinyong Chen, Yanqin Lin, Peter B Barker, Zhong Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Proton-proton scalar coupling plays an important role in molecular structure elucidation. Many methods have been proposed for revealing scalar coupling networks involving chosen protons. However, determining all JHH values within a fully coupled network remains as a tedious process. Here, we propose a method termed as simultaneous multi-slice selective J-resolved spectroscopy (SMS-SEJRES) for simultaneously measuring JHH values out of all coupling networks in a sample within one experiment. In this work, gradient-encoded selective refocusing, PSYCHE decoupling and echo planar spectroscopic imaging (EPSI) detection module are adopted, resulting in different selective J-edited spectra extracted from different spatial positions. The proposed pulse sequence can facilitate the analysis of molecular structures. Therefore, it will interest scientists who would like to efficiently address the structural analysis of molecules.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Magnetic Resonance
Volume282
DOIs
StatePublished - Sep 1 2017

Keywords

  • Echo planar spectroscopic imaging (EPSI)
  • J value
  • PSYCHE
  • Scalar coupling
  • Structure elucidation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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