A simplified route to a key intermediate in the synthesis of the chinese nootropic agent huperzine a

Alan P. Kozikowski, E. Rajarathnam Reddy, Chris P. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient one-pot three-component process for the preparation of 2-pyridones from a carbonyl compound, ammonia, and methyl propiolate has been found which provides ready access to a key intermediate in the synthesis of huperzine A.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number1
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Chemistry(all)

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