A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane

Cong Li; Wing Tak Wong

doi:10.1021/jo026436+

A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane

Cong Li, Wing Tak Wong

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.

Original language	English (US)
Pages (from-to)	2956-2959
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	68
Issue number	7
DOIs	https://doi.org/10.1021/jo026436+
State	Published - Apr 4 2003
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo026436+

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title = "A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane",

abstract = "A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.",

author = "Cong Li and Wong, {Wing Tak}",

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AU - Wong, Wing Tak

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Y1 - 2003/4/4

N2 - A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.

AB - A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.

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A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane

Abstract

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