A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane

Cong Li, Wing Tak Wong

Research output: Contribution to journalArticlepeer-review

Abstract

A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.

Original languageEnglish (US)
Pages (from-to)2956-2959
Number of pages4
JournalJournal of Organic Chemistry
Volume68
Issue number7
DOIs
StatePublished - Apr 4 2003
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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