A simple radiometric in vitro assay for acetylcholinesterase inhibitors

Tomas R. Guilarte, H. Donald Burns, Robert F. Dannals, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

A radiometric method for screening acetylcholinesterase inhibitors has been described. The method is based on the production of [14C]carbon dioxide from the hydrolysis of acetylcholine. The inhibitory concentration at 50% (IC50) values for several known acetylcholinesterase inhibitors were in agreement with literature values. The new radiometric method is simple, inexpensive, and has the potential for automation.

Original languageEnglish (US)
Pages (from-to)90-92
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume72
Issue number1
DOIs
StatePublished - Jan 1983

Keywords

  • Acetylcholinesterase inhibitors—a simple radiometric in vitro assay
  • Radiometric method—in vitro assay for acetylcholinesterase inhibitors

ASJC Scopus subject areas

  • Pharmaceutical Science

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