A Simple Model of the Hemodynamic Effects of a Proximal Coronary Artery Narrowing

Edward H. Klopp, Vincent L. Gott

Research output: Contribution to journalArticle

Abstract

A simple mathematical model of the hemodynamic effects of a discrete proximal coronary artery obstruction is presented. The model demonstrates that resting myocardial flow demands fail to be met when the vessel diameter is decreased by 75% or greater. More strikingly, it shows that the maximum flow obtainable for increased myocardial oxygen demand begins to fall significantly with a lesion causing a 40 to 50% obstruction. The implications of these findings in relation to stress-induced angina are discussed.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalAnnals of Thoracic Surgery
Volume19
Issue number3
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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