A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties

R. Zaczek; A. Markl; M. Balm; J. T. Coyle

doi:10.1016/0165-0270(86)90023-3

A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties

R. Zaczek, A. Markl, M. Balm, J. T. Coyle

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A simple, inexpensive and reliable microcomputer-assisted method to detect and quantify abnormal EEG spiking is described. High frequency wave forms (20-40 Hz) with high amplitude are discriminated using a beta-2 bandpass filter and a threshold comparater. The spikes are then compiled and reported by an Apple II + microcomputer. The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively.

Original language	English (US)
Pages (from-to)	351-360
Number of pages	10
Journal	Journal of Neuroscience Methods
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/0165-0270(86)90023-3
State	Published - Dec 1986

Keywords

Anticonvulsant
EEG
Epilepsy
Excitatory amino acid
Seizure

ASJC Scopus subject areas

General Neuroscience

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10.1016/0165-0270(86)90023-3

Cite this

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title = "A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties",

abstract = "A simple, inexpensive and reliable microcomputer-assisted method to detect and quantify abnormal EEG spiking is described. High frequency wave forms (20-40 Hz) with high amplitude are discriminated using a beta-2 bandpass filter and a threshold comparater. The spikes are then compiled and reported by an Apple II + microcomputer. The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively.",

keywords = "Anticonvulsant, EEG, Epilepsy, Excitatory amino acid, Seizure",

author = "R. Zaczek and A. Markl and M. Balm and Coyle, {J. T.}",

note = "Funding Information: We would like to thank Karl Zurn of Med. Associates, Inc. for his valuable recommendations on the equipment, and Alice Trawinski for her careful secretarial assistance. This research was supported by USPHS Grants RSDA MH-00125 and NS 13584. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1986",

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doi = "10.1016/0165-0270(86)90023-3",

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T1 - A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties

AU - Zaczek, R.

AU - Markl, A.

AU - Balm, M.

AU - Coyle, J. T.

N1 - Funding Information: We would like to thank Karl Zurn of Med. Associates, Inc. for his valuable recommendations on the equipment, and Alice Trawinski for her careful secretarial assistance. This research was supported by USPHS Grants RSDA MH-00125 and NS 13584. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1986/12

Y1 - 1986/12

N2 - A simple, inexpensive and reliable microcomputer-assisted method to detect and quantify abnormal EEG spiking is described. High frequency wave forms (20-40 Hz) with high amplitude are discriminated using a beta-2 bandpass filter and a threshold comparater. The spikes are then compiled and reported by an Apple II + microcomputer. The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively.

AB - A simple, inexpensive and reliable microcomputer-assisted method to detect and quantify abnormal EEG spiking is described. High frequency wave forms (20-40 Hz) with high amplitude are discriminated using a beta-2 bandpass filter and a threshold comparater. The spikes are then compiled and reported by an Apple II + microcomputer. The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively.

KW - Anticonvulsant

KW - EEG

KW - Epilepsy

KW - Excitatory amino acid

KW - Seizure

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A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties

Abstract

Keywords

ASJC Scopus subject areas

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