A simple method of measuring baseline cerebrospinal fluid volume fraction (VCSF) in three-dimensional is proposed that used the characteristic of cerebrospinal fluid with very long T2. It is based on the fitting of monoexponential decay of only cerebrospinal fluid signal, using a nonselective T2 preparation scheme. Three-dimensional gradient- and spin-echo acquisition also improves signal-to-noise ratio efficiency and brain coverage. Both VCSF and T2,CSF are fitted voxel by voxel and analyzed in different cortical areas across subjects. VCSF is largely regionally dependent (occipital: 8.9 ± 1.7%, temporal: 11.4 ± 2.4%, and frontal: 21.4 ± 6.9%). Measured T2,CSF was 1573 ± 146 msec within cortical lobes as compared with 2062 ± 37 msec from ventricle regions. Different parameter set were compared, and the robustness of the new method is demonstrated. Conversely, when comparing with the proposed approach, large overestimation of segmentation based method using T1-weighted images is found, and the underlying causes are suggested.
- CSF volume fraction
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging