A simple and efficient route to the FKBP-binding domain from rapamycin

Research output: Contribution to journalArticle

Abstract

A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer-Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assemble hybrid macrocyclic libraries for the discovery of novel probes of protein function and to synthesize new ligands for the FKBP family of proteins.

Original languageEnglish (US)
Pages (from-to)5070-5072
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number39
DOIs
StatePublished - Sep 28 2011

Keywords

  • FKBP
  • FKBP-binding domain
  • Rapamycin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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