A signal detection theory analysis of behavioral pattern separation paradigms

Rita E. Loiotile, Susan M. Courtney

Research output: Contribution to journalArticlepeer-review

Abstract

Behavioral pattern separation (BPS) paradigms ask participants to discriminate previously encoded (old) stimuli from highly similar (lure) and categorically distinct (novel) stimuli. The lure-old discrimination, thought to uniquely reflect pattern separation in the hippocampal formation, is typically pitted against the traditional novel-old discrimination. However, BPS paradigms have measured lure-old discrimination neither consistently across studies nor in such a way that allows for accurate comparison to novel-old discrimination. Therefore, we advocate for signal detection theory (SDT) as a unified framework. Moreover, we compare SDT with previously used measures of lure-old discrimination, indicating how other formulas' inaccuracies can lead to erroneous conclusions.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalLearning and Memory
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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