A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue

A. Ravi Kumar, N. Sudhakar, B. Venkateswara Rao, N. Raghunandan, A. Venkatesh, M. Sarangapani

Research output: Contribution to journalArticlepeer-review

Abstract

A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its analogue using Evans protocol is described.

Original languageEnglish (US)
Pages (from-to)2085-2086
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number8
DOIs
StatePublished - Apr 15 2005
Externally publishedYes

Keywords

  • Chiral auxiliary
  • Cytotoxic activity
  • Evans-asymmetric aldol methodology
  • Tempo oxidation
  • δ-Lactones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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