A short, simple and general approach for the synthesis of (3S,4S)-3-methoxy-4-methylamino pyrrolidine and (3S,4R)-3-methoxy-4-methylamino pyrrolidine

A. Ravi Kumar, J. Santhosh Reddy, B. Venkateswara Rao

Research output: Contribution to journalArticle

Abstract

A general and efficient stereoselective approach for the synthesis of (3S,4S) and (3S,4R)-3-methoxy-4-methylamino pyrrolidines, a part of the structure of AG-7352, a naphthyridine antitumor agent and quinoline antibacterial compounds has been described.

Original languageEnglish (US)
Pages (from-to)5687-5689
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number30
DOIs
StatePublished - Jul 21 2003
Externally publishedYes

Keywords

  • Amino ditosylated compounds
  • Chiral pyrrolidines
  • Regioselective cyclization
  • S displacement

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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