A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

Zhi Liang Wei; Alan P. Kozikowski

doi:10.1021/jo035140g

A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

Zhi Liang Wei, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

Original language	English (US)
Pages (from-to)	9116-9118
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	68
Issue number	23
DOIs	https://doi.org/10.1021/jo035140g
State	Published - Nov 14 2003

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo035140g

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abstract = "The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.",

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AB - The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

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A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

Abstract

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