A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

Zhi Liang Wei, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

Original languageEnglish (US)
Pages (from-to)9116-9118
Number of pages3
JournalJournal of Organic Chemistry
Volume68
Issue number23
DOIs
StatePublished - Nov 14 2003

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ'. Together they form a unique fingerprint.

Cite this