A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

Zhi Liang Wei, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

Original languageEnglish (US)
Pages (from-to)9116-9118
Number of pages3
JournalJournal of Organic Chemistry
Volume68
Issue number23
DOIs
StatePublished - Nov 14 2003
Externally publishedYes

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Peroxisome Proliferator-Activated Receptors
GW 501516
2-cresol

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ. / Wei, Zhi Liang; Kozikowski, Alan P.

In: Journal of Organic Chemistry, Vol. 68, No. 23, 14.11.2003, p. 9116-9118.

Research output: Contribution to journalArticle

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