A serial risk score approach to disease classification that accounts for accuracy and cost

Dat Huynh, Oliver B. Laeyendecker, Ron Brookmeyer

Research output: Contribution to journalArticle

Abstract

The performance of diagnostic tests for disease classification is often measured by accuracy (e.g., sensitivity or specificity); however, costs of the diagnostic test are a concern as well. Combinations of multiple diagnostic tests may improve accuracy, but incur additional costs. Here, we consider serial testing approaches that maintain accuracy while controlling costs of the diagnostic tests. We present a serial risk score classification approach. The basic idea is to sequentially test with additional diagnostic tests just until persons are classified. In this way, it is not necessary to test all persons with all tests. The methods are studied in simulations and compared with logistic regression. We applied the methods to data from HIV cohort studies to identify HIV infected individuals who are recently infected (

Original languageEnglish (US)
Pages (from-to)1042-1051
Number of pages10
JournalBiometrics
Volume70
Issue number4
DOIs
StatePublished - Dec 1 2014

Fingerprint

Diagnostic Tests
Routine Diagnostic Tests
diagnostic techniques
Costs and Cost Analysis
Costs
Person
testing
Logistics
HIV
Multiple Tests
Cohort Study
Logistic Regression
cohort studies
Testing
Specificity
Cohort Studies
Logistic Models
Sensitivity and Specificity
Necessary
methodology

Keywords

  • Biomarkers
  • Classification
  • Diagnostic tests
  • HIV

ASJC Scopus subject areas

  • Applied Mathematics
  • Statistics and Probability
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

A serial risk score approach to disease classification that accounts for accuracy and cost. / Huynh, Dat; Laeyendecker, Oliver B.; Brookmeyer, Ron.

In: Biometrics, Vol. 70, No. 4, 01.12.2014, p. 1042-1051.

Research output: Contribution to journalArticle

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