Abstract
Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of λ-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the λ-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis.
Original language | English (US) |
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Pages (from-to) | 113-116 |
Number of pages | 4 |
Journal | Journal of Pharmacological Sciences |
Volume | 103 |
Issue number | 1 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Keywords
- Arthritis
- Gait analysis
- Quantification
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology