A sensitive gait parameter for quantification of arthritis in rats

Kensuke Orito, Shogo Kurozumi, Idaku Ishii, Akane Tanaka, Junko Sawada, Hiroshi Matsuda

Research output: Contribution to journalArticle

Abstract

Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of λ-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the λ-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalJournal of Pharmacological Sciences
Volume103
Issue number1
DOIs
Publication statusPublished - Feb 2 2007
Externally publishedYes

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Keywords

  • Arthritis
  • Gait analysis
  • Quantification

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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