A second sequence element located 3' to the NF-κB-binding site regulates IL-2 receptor-α gene induction

J. L. Pomerantz, F. Mauxion, M. Yoshida, W. C. Greene, R. Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Transcriptional induction of the gene encoding the α-subunit of IL-2R has been shown to be mediated by a sequence element (GGGGAATCTCCC) that is homologous to the NF-κB-binding site of the κ Ig gene enhancer. In this report we demonstrate that the induced transcription of this gene by mitogen and by the tax gene product of the type-I human T cell leukemia virus is dependent upon an additional sequence motif (GGGCGTAGC) located approximately 10 bp downstream of the previously identified site. This newly identified motif binds a factor that is present in extracts derived from different cell types and does not appear to be required for basal promoter activity. We conclude that proteins binding at both sites act coordinately, leading to maximal induction of the receptor gene.

Original languageEnglish (US)
Pages (from-to)4275-4281
Number of pages7
JournalJournal of Immunology
Volume143
Issue number12
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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